Who should avoid resveratrol?

Understanding Resveratrol and Its Risks
Resveratrol, a natural polyphenol found in various plants, has garnered attention for its potential health benefits, particularly in relation to heart health and longevity. However, while it may offer advantages for some, there are specific groups of individuals who should exercise caution or avoid its use altogether.
Who Should Avoid Resveratrol?
1. Individuals with Liver Conditions: Those suffering from nonalcoholic fatty liver disease (NAFLD) should be particularly wary of resveratrol. Research indicates that taking resveratrol does not improve liver function or cholesterol levels in these patients, and it may not provide any therapeutic benefits for liver health. Given the liver’s crucial role in metabolizing substances, introducing resveratrol could potentially complicate existing liver issues.
2. Pregnant and Breastfeeding Women: Pregnant and breastfeeding women are generally advised to avoid supplements that have not been thoroughly studied for safety in these populations. The effects of resveratrol during pregnancy and lactation are not well understood, and caution is warranted to prevent any potential risks to the developing fetus or nursing infant.
3. Individuals on Blood Thinners: Resveratrol has been noted for its blood-thinning properties, which can pose risks for individuals taking anticoagulant medications such as warfarin. The combination could enhance the effects of these medications, leading to an increased risk of bleeding. Therefore, those on blood thinners should consult their healthcare provider before considering resveratrol supplementation.
4. People with Hormone-Sensitive Conditions: Resveratrol exhibits both estrogenic and anti-estrogenic properties, which may influence hormone levels in the body. Individuals with hormone-sensitive conditions, such as certain types of breast cancer, should be cautious, as resveratrol could potentially exacerbate their condition.
5. Those with Allergies to Grapes or Wine: Since resveratrol is commonly associated with red wine and grapes, individuals with allergies to these foods should avoid resveratrol supplements to prevent allergic reactions.
Conclusion
While resveratrol may hold promise for various health benefits, it is not suitable for everyone. Individuals with liver conditions, pregnant or breastfeeding women, those on blood thinners, people with hormone-sensitive conditions, and those with allergies to grapes should approach resveratrol with caution. As always, consulting with a healthcare professional before starting any new supplement is advisable to ensure safety and appropriateness based on individual health circumstances.

Does resveratrol raise estrogen?

In some situations, high doses of resveratrol boost the activity of estrogen, in others they block estrogen. That makes resveratrol supplements iffy for women with cancer of the breast, ovary, uterus, or other estrogen-sensitive tissue, those trying to become pregnant, or those taking an oral contraceptive.

What is better than resveratrol?

Pterostilbene has a slightly different structure that makes it more bioavailable than resveratrol. Pterostilbene is a potent activator of SIRT1, an NAD(+)-dependent enzyme that plays a critical role in cellular health and DNA maintenance.

What are the negative side effects of resveratrol?

In a phase II clinical trial on patients with refractory multiple myeloma, a daily dose of 5.0 g of RE was administered. Side effects of RE including nausea, diarrhea, fatigue, and renal toxicity might have caused the loss of this patient [186].

Is resveratrol safe for everyone?

When you get resveratrol in the amount naturally found in foods, it is generally considered safe. It could cause a reaction in those who are allergic to grapes or wine. People who have health conditions like bleeding disorders should not take resveratrol without talking to a doctor first.

Is resveratrol linked to cancer?

Resveratrol affects a variety of cancer stages from initiation and promotion to progression by affecting the diverse signal-transduction pathways that control cell growth and division, inflammation, apoptosis, metastasis, and angiogenesis.

Can resveratrol damage kidneys?

Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ.

What supplements are hard on the liver?

The major implicated agents include anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS).

Is resveratrol bad for kidneys?

Undeniably, resveratrol supplementation could represent a promising therapy to attenuate the progression of CKD, affect azotemia, and reduce morbidity and mortality by preventing or minimizing the risk of cardiovascular disease in patients with CKD.

Why is resveratrol controversial?

Despite these results, resveratrol still carries some uncertainties and controversies. One significant uncertainty surrounding resveratrol is its poor bioavailability when taken orally. Studies have shown that resveratrol is rapidly metabolized and excreted, resulting in limited bioavailability.

Is resveratrol toxic to liver?

Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats.