What are the side effects of Zofran for nurses?

Understanding Zofran and Its Side Effects for Nurses
Zofran, known generically as ondansetron, is a widely used medication primarily prescribed to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and postoperative recovery. While it is generally well-tolerated, nurses must be aware of its potential side effects to provide comprehensive care and manage patient expectations effectively.
Common Side Effects
The most frequently reported side effects of Zofran include headaches, fatigue, dry mouth, constipation, and diarrhea. Clinical studies indicate that headaches occur in more than 10% of adult patients, making it one of the most common complaints following administration. Fatigue and malaisePotential Side Effects of Zofran (Ondansetron) for Nurses
As a nurse, it’s important to be aware of the potential side effects associated with the medication Zofran (ondansetron), which is commonly used to prevent nausea and vomiting caused by surgery, chemotherapy, or radiation therapy.
Headaches: According to the National Institutes of Health (NIH), headaches are one of the most commonly reported side effects of ondansetron, occurring in more than 10% of adult patients.
Fatigue and Malaise: The NIH also lists fatigue and malaise (general discomfort or uneasiness) as common side effects, again occurring in over 10% of adult patients.
Dry Mouth: Dry mouth is another frequently reported side effect, affecting up to 10% of patients taking ondansetron. ,
Constipation: Constipation is a relatively common side effect, reported in 6-11% of patients receiving ondansetron for chemotherapy-induced nausea and vomiting.
Diarrhea: Conversely, diarrhea has also been reported in 2-16% of patients taking ondansetron for chemotherapy-induced nausea and vomiting.
Drowsiness and Sedation: While less common, ondansetron injection has been reported to cause drowsiness or sedation in up to 8% of patients, compared to 7% in those receiving a placebo.
It’s important for nurses to be aware of these potential side effects and monitor patients closely, especially when first starting ondansetron treatment. Patients should be advised to report any concerning side effects to their healthcare provider. By understanding the common side effects of Zofran, nurses can provide better care and support for their patients.

What should the nurse monitor with ondansetron?

Monitor improvements in GI symptoms (decreased nausea and vomiting, increased appetite) to help document whether drug therapy is successful. Assess motor function, and report any extrapyramidal reactions.

What precautions should be taken when taking Zofran?

This medicine may cause a serious heart problem called myocardial ischemia (low blood supply to the heart). Check with your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, sweating, trouble breathing, irregular heartbeat, or vomiting.

What is the role of Zofran in nursing?

Ondansetron is a serotonin (5HT3) receptor antagonist used for the prevention and treatment of postoperative nausea and vomiting.

What is the downside to Zofran?

Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat. Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting.

What organ does Zofran affect?

Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. This medicine is available only with your doctor’s prescription. This product is available in the following dosage forms: Tablet, Disintegrating.

What is the most common side effect of Zofran?

Common side effects of Zofran (Ondansetron) include headache, constipation, diarrhea, and dizziness. Serious side effects can include serotonin syndrome and cardiac arrhythmias such as QT prolongation and torsade de pointes.

What are the negative interactions of Zofran?

This medication may also interact with the following: Carbamazepine. Certain medications for depression, anxiety, or psychotic disturbances. Fentanyl.

What should be monitored when taking Zofran?

While taking Zofran (ondansetron), your healthcare professional may occasionally order an electrocardiogram (ECG, EKG) to monitor your heart rate and rhythm. Seek immediate care if you experience an irregular heartbeat, shortness of breath, dizziness, or fainting while taking Zofran (ondansetron).

Why was Zofran discontinued?

WASHINGTON — The 32-mg dose of the anti-nausea drug ondansetron (Zofran) has been pulled from the market because of concerns about cardiac problems, the FDA announced Tuesday. Ondansetron is approved for preventing chemotherapy-induced nausea and vomiting, and, in lower doses, for postoperative nausea and vomiting.

Which common adverse effect of ondansetron would the nurse teach the patient to report?

Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat. Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting.