Page Content
- Is it safe to take resveratrol daily?
- What medications should not be taken with resveratrol?
- Does resveratrol affect the heart?
- What happens when you stop taking resveratrol?
- What is better than resveratrol?
- Who should avoid resveratrol?
- Can resveratrol raise blood pressure?
- Is resveratrol toxic to liver?
- What supplements are hard on the liver?
- Is resveratrol hard on the liver?
Understanding the Side Effects of Resveratrol
Resveratrol, a natural polyphenol found in various plants, particularly in grape skins and red wine, has garnered significant attention for its potential health benefits. However, as with any supplement, it is essential to consider the possible side effects associated with its use.
General Safety Profile
Research indicates that resveratrol is generally safe when consumed in moderate amounts. Studies suggest that doses up to 1500 mg daily can be taken safely for up to three months, while higher doses, ranging from 2000 to 3000 mg, have been used for periods of two to six months without severe adverse effects. Notably, when resveratrol is consumed in the amounts typically found in food, it is considered safe for most individuals.
Common Side Effects
Despite its safety profile, some users may experience mild to moderate gastrointestinal issues. These can include symptoms such as nausea, abdominal pain, flatulence, and diarrhea. Such side effects are more likely to occur at higher doses, particularly when exceeding 2500 mg per day . For instance, a clinical trial noted that a single high dose of 5000 mg resulted in no serious adverse effects, but participants did report mild gastrointestinal discomfort.
Hormonal Effects and Gene Expression
Resveratrol’s interaction with hormonal pathways is another area of concern. It has been observed that resveratrol can influence gene expression, particularly in cancer cells, which may have implications for hormone-dependent cancers. While this effect could potentially be beneficial in some contexts, it raises questions about the long-term impact of resveratrol supplementation, especially for individuals with a history of hormone-sensitive conditions.
Conclusion
In summary, while resveratrol is widely regarded as safe, particularly in dietary amounts, users should be mindful of the potential for gastrointestinal side effects, especially at higher doses. As research continues to evolve, it remains crucial for individuals considering resveratrol supplements to consult healthcare professionals, particularly if they have underlying health conditions or are taking other medications. The balance between its promising health benefits and the risk of side effects underscores the importance of informed and cautious use.
Is it safe to take resveratrol daily?
Clinical trials show that it is technically safe to take resveratrol in doses of up to 5 g per day , though taking more than 2.5 g per day is likely to result in abdominal side effects such as cramping, flatulence, and nausea.
What medications should not be taken with resveratrol?
Interactions
| Drug | Interaction |
|---|---|
| Integrate drug-drug interactions in your software | |
| Clopidogrel | Clopidogrel may increase the antiplatelet activities of Resveratrol. |
| Cyclophosphamide | The risk or severity of bleeding can be increased when Resveratrol is combined with Cyclophosphamide. |
Does resveratrol affect the heart?
According to the literature, RES can improve the diastolic and systolic function of the heart, it can reduce atrial and left ventricular remodeling, and it can improve cardiac energetics, which may contribute to the cardioprotective effects of RES in heart failure.
What happens when you stop taking resveratrol?
What happens if I stop it? Resveratrol does not have known withdrawal problems. Currently the best option is TruNature Resveratrol Plus (available on Amazon). It comes as 250mg so take 2/day.
What is better than resveratrol?
Pterostilbene has a slightly different structure that makes it more bioavailable than resveratrol. Pterostilbene is a potent activator of SIRT1, an NAD(+)-dependent enzyme that plays a critical role in cellular health and DNA maintenance.
Who should avoid resveratrol?
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use resveratrol.
Can resveratrol raise blood pressure?
Resveratrol Supplements May Help Lower Blood Pressure
Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure ( 9 ). A 2015 review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats ( 3 ).
Is resveratrol toxic to liver?
Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats.
What supplements are hard on the liver?
The major implicated agents include anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS).
Is resveratrol hard on the liver?
Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats.
