How long does it take for Excedrin to wear off?

Understanding Excedrin: Duration and Effects
Excedrin, a popular over-the-counter medication, combines acetaminophen, aspirin, and caffeine to provide relief from various types of pain, particularly headaches and migraines. Many users often wonder how long it takes for the effects of Excedrin to wear off after taking it.
Onset of Action
When taken, Excedrin can start to alleviate headache pain relatively quickly. For instance, Excedrin Migraine has been shown to work as fast as 30 minutes in clinical studies. However, for Excedrin Extra Strength, users might experience relief in about one to two hours. This variability in onset can depend on several factors, including the individual’s metabolism, the severity of the headache, and whether the medication is taken on an empty stomach.
Duration of Effects
The duration of Excedrin’s effectiveness is influenced by its ingredients. The pain-relieving effects of acetaminophen and aspirin can last for several hours, typically around 4 to 6 hours. However, the effects of aspirin can linger longer due to its unique mechanism of action; it affects platelets in the bloodstream, which can last for about 10 days after the last dose. This means that while the immediate pain relief may wear off within a few hours, the physiological effects of aspirin can persist much longer.
Considerations for Use
It’s important for users to be mindful of how often they take Excedrin. Regular use can lead to rebound headaches, where the medication can inadvertently cause more headaches rather than alleviate them. Therefore, it is generally recommended not to exceed taking Excedrin more than three times a week.
In summary, while Excedrin can provide quick relief from headaches, the duration of its effects varies based on the formulation and individual factors. Users should be aware of both the immediate and longer-lasting impacts of its ingredients to use it effectively and safely.

What to take for a headache before bed?

Possible treatments
Indomethacin (Indocin) — a nonsteroidal anti-inflammatory medication. Caffeine — taken as a tablet or beverage before bedtime.

Can I sleep after taking Excedrin?

Because this product contains caffeine, taking it close to bedtime may give you trouble falling asleep. Limit the use of caffeine-containing medications, foods, or beverages while taking this product. If you take too much caffeine, you may become nervous or irritable, have trouble sleeping, or have fast heartbeat.

How to stop stomach pain from Excedrin?

Take Excedrin with food or milk if it makes your stomach upset. Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever lasting longer than 3 days, or any swelling or pain lasting longer than 10 days.

How long is Excedrin supposed to last?

Key Points. Excedrin Migraine can work as quickly as 30 minutes to relieve your migraine pain. In clinical studies, patients with moderate to severe migraines experienced pain relief with one dose and it lasted up to 6 hours. Excedrin Migraine is taken as soon as your migraine headache begins.

Why do I feel weird after taking Excedrin?

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.

Is Excedrin hard on your stomach?

Both medications are available over the counter (OTC) as tablets and caplets with brand name and generic versions. Possible side effects include trouble sleeping, dizziness, and upset stomach.

How long does Excedrin last?

Key Points. Excedrin Migraine can work as quickly as 30 minutes to relieve your migraine pain. In clinical studies, patients with moderate to severe migraines experienced pain relief with one dose and it lasted up to 6 hours. Excedrin Migraine is taken as soon as your migraine headache begins.

Is taking 2 Excedrin a day bad for you?

Acetaminophen, one of the drugs in Excedrin Migraine, can cause severe liver damage. You have a higher risk of liver damage if you take Excedrin Migraine and do any of the following: use more than the maximum daily amount (two caplets in 24 hours) take other products that contain acetaminophen.

What is a good substitute for Excedrin?

• Sumatriptan.
• Imitrex.
• Ubrelvy.
• Nurtec ODT.
• Rizatriptan.
• Memantine.

How long does it take Excedrin to wear off?

How long does Excedrin Migraine last? In three placebo-controlled studies, an acetaminophen, aspirin, and caffeine combination (equivalent to Excedrin Migraine) was shown to last up to 6 hours when taken to relieve migraine headache pain.